Xenobiotic metabolism an overview sciencedirect topics. Cytochrome p450 enzymes are involved in the phase i of xenobiotic metabolism, including pharmaceuticals, and in endogenous. Xenobiotic definition of xenobiotic by medical dictionary. A xenobiotic is a chemical substance found within an organism that is not naturally produced or expected to be present within the organism. It can also cover substances that are present in much higher concentrations than are usual. Pdf xenobiotic compounds are man made chemicals that are present in the environment at higher concentration. Learn how to easily convert a microsoft powerpoint. Cytochrome p450 system and xenobiotic metabolism request pdf. The term xenobiotics, however, is very often used in the context of pollutants such as dioxins and polychlorinated biphenyls and their effect on the biota, because xenobiotics are understood as substances foreign to an entire biological system, i. Save powerpoint presentations as pdf files office support. A free powerpoint ppt presentation displayed as a flash slide show on id. Farmacos, aditivos alimenticios, contaminantes ambientales, carcinogenos quimicos, insecticidas y otros.
Society logo in use prior to 2008 an examination of the fate of foreign compounds xenobiotics in biological systems is a natural outgrowth of mans curiosity about his environment and how it can affect his actions. Hormonally active agents haas human and animal estrogens, detergent residues, and low volatility solvents. Ppt xenobiotics powerpoint presentation free to view. Summary xenobiotics are chemical compounds foreign to thebody, such as drugs, food additives, and environmentalpollutants xenobiotics are metabolized in two phases.
Edward croom, in progress in molecular biology and translational science, 2012. Powerpoint to pdf convert your ppt to pdf for free online zamzar. Pdf xenobiotic compounds and their types xenobiotic. Water, sanitation, health protocol on water and health signed by 34 countries, ratified by 15 expert groups technical and working groups political. Basic considerations in the dermatokinetics of topical.
Under print quality paper pdf, set the desired quality to an option of your choice. Descargue como ppt, pdf, txt o lea en linea desde scribd. Chart and diagram slides for powerpoint beautifully designed chart and diagram s for powerpoint with visually stunning graphics and animation effects. Ppt to pdf converter convert your powerpoint to pdf online free.
Many businesses and students that have to present something will almost always do their presentation using microsoft powerpoint. History of xenobiotic metabolism international society. For volatile chemicals, the lungs serve as an additional route of elimination. Liver and biotransformation of xenobiotics functions of. Our new crystalgraphics chart and diagram slides for powerpoint is a collection of over impressively designed datadriven chart and editable diagram s guaranteed to impress any audience. The enzymes involved are a somewhat heterogeneous bunch and primarily serve in roles other than the metabolism of xenobiotics. In the powerpoint preferences dialog box, click general. Without metabolism, many xenobiotics would reach toxic concentrations. Estimates of the number of distinct cytochrome p450s in human tissues range from approximately 35 to 60. Ppt microbiologia do solo powerpoint presentation free.
The reactive species of a xenobiotic may bind to aprotein, altering its antigenicity the resulting antibodies can then damage the cell byseveral immunologic mechanisms that grossly perturbnormal cellular biochemical processes. Xenobiotics have been defined as chemicals to which an organism is exposed that are extrinsic to the normal metabolism of that organism. Skin barriers skin is the largest organ of human body, which also act as a boundary between body and environment. The reaction catalyzed by a monooxygenase cytochrome p450 is as follows. It protects the body from chemical, physical, and microbial injury, loss of water, and other endogenous substances waugh, grant, 2004. Theyll give your presentations a professional, memorable appearance the kind of sophisticated look that todays audiences expect. Xenobiotic compounds and their types xenobiotic compounds and its types. Pdf converter is a online webbased document to pdf converter software. Convert and create pdf from various types of files like word doc, excel xls, powerpoint ppt. History of xenobiotic metabolism international society for.
The responsible enzymes are called monooxygenases or cytochrome p450s. In the environment, xenobiotics include synthetic pesticides, herbicides, and industrial. Biotransformacion farmacologica farmacologia basica y. With respect to animals and humans, xenobiotics include drugs, drug metabolites, and environmental compounds such as pollutants that are not produced by the body. Cell injury cytotoxicity, can be severe enough toresult in cell death. Usa c bioquimica compuestos u a glucuronidacion glucu. Xenobiotic compounds are man made chemicals that are present in the environment at higher concentration. Ppt xenobiotics powerpoint presentation free to view id. No file size restrictions, no ad watermarks just a free online tool for creating pdfs from your ppt slides. To make use of a compound or to facilitate its excretion increases the water solubility of a compound divided in two phases, phase i and phase ii. The bad breath associated with eating onions and garlic is partly due to the exhalation of volatile compounds found in these vegetables that are leaving through the lungs.
The majorreaction of phase 1 is hydroxylation catalyzed by a varietyof monooxygenases, also known as the cytochromep450s. Follow these instructions to set the print quality of the pdf. Use soda pdfs online converter tool and convert powerpoint to pdf for free. Xenobiotic metabolism functions primarily to increase the polarity of xenobiotics, making them easier to excrete. Scribd is the worlds largest social reading and publishing site. Liver composes of four lobes divided into lobules which are surrounded by blood vessels.
Metabolismo dos xenobioticos importancia biomedica xenobioticos os seres humanos estao cada vez mais expostos a diversas substancias quimicas estranhas xenobioticos farmacos, aditivos alimentares, poluentes etc. They will contain structural elements that are unknown or rare in nature andor are assembled in a structure which is not of natural occurrence. Phase i reactions involve hydrolysis, reduction, and oxidation. These are synthetic chemicals and are not found in nature. Os xenobioticos e a microbiota intestinal xenobioticos. Liver is the second largest organ in the body the largest is skin, weighing approximately 1,5 kg.
Xenobiotic biotransformation is accomplished by a limited number of enzymes with broad substrate specificities. Broad range of contaminants that are now being found in the environment. Effects of xenobiotics metabolism of a xenobiotic can result in cellinjury, immunologic damage, or cancer. Oct 18, 2015 hydroxylation is the chief reaction involved in phase 1. Nov 23, 2012 summary xenobiotics are chemical compounds foreign to thebody, such as drugs, food additives, and environmentalpollutants xenobiotics are metabolized in two phases. Worlds best powerpoint templates crystalgraphics offers more powerpoint templates than anyone else in the world, with over 4 million to choose from. Disposition of xenobiotics absorption, distribution and excretion of xenobiotics benay can eke, ph.
These macromolecular targets include dna, rna, andprotein. Xenobioticos sao compostos quimicos estranhos ao organismo humano. Winner of the standing ovation award for best powerpoint templates from presentations magazine. We note that in the european region about one third of the total burden of disease from birth to 18 years can be. Make ppt and pptx slideshows easy to view by converting them to pdf. Biotransformation is the metabolic conversion of endogenous and xenobiotic chemicals to more watersoluble compounds. Baixe no formato ppt, pdf, txt ou leia online no scribd. Liver and biotransformation of xenobiotics functions.
It can also cover substances that are present in much higher concentrations than are usual natural compounds can also become xenobiotics if they are taken up by another organism, such as the uptake of natural human hormones by fish found downstream of. These are either not produced naturally or are produced at much lower amount than that by. It is a term applied to many recalcitrant organic chemicals. Hydroxylation is the chief reaction involved in phase 1.
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